Database : HANSEN Search on : ANALISE POR CONGLOMERADOS [Subject descriptor] References found : 6 [refine] Displaying: 1 .. 6   in format [Detailed]

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Id: 17277 Author: Mohammad, Hatta Title: Epidemiology of leprosy: molecular, biological, and immunological approach ..- Source: s.l; s.n; 2003. 10 p. tab. Abstract: Leprosy is an infectious disease for which humans are considered the only source of infection. The major hindrance in leprosy control and thus in reaching the elimination goal is that numerous leprosy cases remain undetected for a long time. Many of these patients are a continuous source of infection and, and hence perpetuate transmission. The goal of the World Health Organization (WHO) is to eliminate leprosy as a public problem by the year 2000; that is, to reach as a global prevalence of <1 per 10,000 people. The epidemiological data generated routinely by health services are greatly influenced by their policies and activities. The data do not, however necessarily reflect the true situation in the field. Information on the magnitude of the leprosy problem in any one area is important for the health services with regard to their planning, monitoring and evaluation of leprosy control activities. Our studies have suggested that the high prevalence of antibodies in children may be indicative of the active transmission of M. leprae in their surroundings. The prevalence of these antibodies may also be important for leprosy control programs in order to detect new patients as early as possible and in an effective and sustainable manner. Based on PCR data, it seems that the environment also plays an important role in the transmission of leprosy in endemic areas. The results of our study show that contact with a leprosy patient is the major determinant in the incidence of leprosy and that this concept shows similarities with the "stone-in-the-pond" principle of tuberculosis transmission in concentric circle around patients. (AU). Descriptors: Anticorpos Análise por Conglomerados DNA Bacteriano Predisposição Genética para Doença/*GE Geografia Incidência Hanseníase/BL/*EP/TM Mycobacterium leprae/GE/*PY Prevalência Estudos Soroepidemiológicos Limits: Humano Location: BR191.1; 09176/s

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Id: 17275 Author: Bleharski, Joshua R; Li, Huiying; Meinken, Cristoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Title: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Source: s.l; s.n; 2003. 4 p. . Abstract: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descriptors: Algoritmos Análise por Conglomerados Contagem de Colônia Microbiana Citocinas/GE/ME Perfilação da Expressão Gênica/* Regulação da Expressão Gênica/* Genes de Imunoglobulinas Imunidade Celular Imunidade Natural Hanseníase Virchowiana/*CL/*GE/IM/PP Hanseníase Tuberculóide/*CL/*GE/IM/PP Macrófagos Alveolares/MI Glicoproteínas de Membrana/IM Mycobacterium tuberculosis/GD/IM Análise de Sequência com Séries de Oligonucleotídeos Reação em Cadeia da Polimerase Análise de Componente Principal Receptores da Superfície Celular/IM Receptores Imunológicos/GE/ME Limits: Humano Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Regulação para Cima Location: BR191.1; 09174/s

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Id: 13656 Author: Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Title: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Source: s.l; s.n; Sep. 2003. 4 p. graf. Abstract: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descriptors: HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/fisiopatol HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/genet HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/fisiopatol CITOCINAS/genet CITOCINAS/metab PERFILACAO DA EXPRESSÃO GÊNICA ANALISE POR CONGLOMERADOS CONTAGEM DE COLÔNIA MICROBIANA REGULACAO DA EXPRESSÃO GÊNICA IMUNIDADE CELULAR IMUNIDADE NATURAL MACROFAGOS ALVEOLARES/microbiol GLICOPROTEINAS DE MEMBRANA/imunol MYCOBACTERIUM TUBERCULOSIS/cresc MYCOBACTERIUM TUBERCULOSIS/imunol REACAO EM CADEIA DA POLIMERASE RECEPTORES IMUNOLOGICOS/genet RECEPTORES IMUNOLOGICOS/metab RECEPTORES DA SUPERFICIE CELULAR/imunol - REGULACAO PARA CIMA  Análise de Componente Principal  ALGORITMOS  GENES DE IMUNOGLOBULINAS  ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS Limits: SUPPORT, NON-U.S. GOV'T HUMANO SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09142/s; BR191.1; 09145/s

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Id: 11620 Author: Lapa, Tiago; Ximenes, Ricardo; Silva, Nilza Nunes; Souza, Wayner; Albuquerque, Maria de Fátima Militão; Campozana, Gisele Title: Vigilância da hanseníase em Olinda. Brasil, utilizando técnicas de análise espacial Leprosy surveillance in Olinda, Brazil, Using spatial analysis techniques- Source: Rio de Janeiro; s.n; set-out., 2001. 10 p. tab, graf, mapas. Descriptors: HANSENIASE HANSENIASE ANALISE DE VARIANCIA FATORES DE RISCO FATORES SOCIO-ECONOMICOS POPULAÇAO URBANA ANALISE POR CONGLOMERADOS Location: BR191.1; 08443/s; BR191.1; 08685/s

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Id: 9893 Author: Hatta, Mochammad; Van Beers, Stella M; Madjid, Baedah; Djumadi, Achmad; de Wit, Madeleine Y. L; Klatser, R Title: Distribution and persistence of Mycobacterium leprae nasal carriage among a population in which leprosy is endemic in Indonesia ..- Source: s.l; s.n; 1995. 5 p. ilus, tab. Descriptors: ADOLESCENCIA ANTICORPOS ANTIBACTÉRIAS PORTADOR PORTADOR CRIANÇA CRECHES PRÉ-ESCOLAR ANALISE POR CONGLOMERADOS SEGUIMENTOS INDONÉSIA HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE NARIZ REAÇAO EM CADEIA POR POLIMERASE PREVALENCIA Location: BR191.1; 06784/s

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Id: 9325 Author: Myint, Tin; Htoon, Myo Thet; Shwe, Tin Title: Estimation of leprosy prevalence in Bago and Kawa Townships using two-stage probability proportionate to size sampling technique ..- Source: s.l; s.n; 1992. 6 p. tab. Descriptors: ADOLESCENCIA PRÉ-ESCOLAR ANALISE POR CONGLOMERADOS LEVANTAMENTOS EPIDEMIOLOGICOS INDIA LACTENTE HANSENIASE PREVALENCIA PROBABILIDADE Location: BR191.1; 06476/s

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